Betaxolol Hydrochloride is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.; Target: Beta1 Adrenergic Receptor; Betaxolol is a cardioselective beta-adrenergic receptor blocking agent. MedChem Express HY-B0381A 5 Citations for Betaxolol hydrochloride. Citations are publications that use Tocris products. Selected citations for Betaxolol hydrochloride include: Schutsky et al (2011) Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling. Betaxolol is classified as pregnancy risk category C by the FDA. Animal studies indicate the drug is not teratogenic. There are no adequate and well-controlled studies in pregnant women; however, systemically administered beta-blockers have been shown to reduce placental perfusion, which may result in intrauterine fetal death or premature delivery. Betaxolol is a competitive, beta(1)-selective (cardioselective) adrenergic antagonist. Betaxolol is used to treat hypertension, arrhythmias, coronary heart disease, glaucoma, and is also used to reduce non-fatal cardiac events in patients with heart failure. Betaxolol Hydrochloride. text.skipToContent text.skipToNavigation. TCI uses cookies to personalize and improve your user experience. By continuing on our website, you accept the use of cookies. You can change or update your cookiesettings at any time. Accept. Published TCIMAIL newest issue No.185. Betaxolol attenuates the NMDA-induced influx of 45 Ca 2+ while β-adrenoreceptor agonists are ineffective. The glutamate-induced release of LDH is almost completely prevented when betaxolol (10 μM) is included. Betaxolol (100 μM) is very effective in preventing the hypoxia-induced release of LDH from cortical cultures. In vivo Betaxolol is a propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydoxy is substituted by a 4-[2-(cyclopropylmethoxy)ethyl]phenyl group and one of the hydrogens attached to the amino group is substituted by isopropyl. It is a selective beta1-receptor blocker and is used in the treatment of glaucoma as well as hypertension, arrhythmias, and coronary heart disease. Betaxolol (hydrochloride) SAFETY DATA SHEET Specific Gravity (Water = 1): No data. Solubility in Water: No data. Solubility Notes: ~10 mg/ml in PBS (pH 7.2); ~25 mg/ml in EtOH, DMSO &, DMF; Autoignition Pt: No data. Percent Volatile: No data. 9.2 Other Information Molecular Formula & Weight: C18H29NO3 • HCl 343.9 10.4 10.5 10.6 10.1 10.2 10.3 Synonyms Betaxolol HCl UNII 6X97D2XT0O CAS Number 63659-19-8 Weight Average: 343.889 Monoisotopic: 343.191421538 Chemical Formula C 18 H 30 ClNO 3 InChI Key CHDPSNLJFOQTRK-UHFFFAOYSA-N Betaxolol hydrochloride produces less systemic beta 2- and possibly beta 1-adrenergic receptor blockade than either timolol or levobunolol. Betaxolol hydrochloride may be relatively safer to use in patients with reactive airway disease than either timolol or levobunolol [2]. MCE has not independently confirmed the accuracy of these methods.
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